Mika Leinonen Selected Research

entacapone (Comtan)

12/2015	Efficacy and safety of entacapone in levodopa/carbidopa versus levodopa/benserazide treated Parkinson's disease patients with wearing-off.
7/2013	Factors predictive of the development of Levodopa-induced dyskinesia and wearing-off in Parkinson's disease.
3/2010	Direct switch from levodopa/benserazide or levodopa/carbidopa to levodopa/carbidopa/entacapone in Parkinson's disease patients with wearing-off: efficacy, safety and feasibility--an open-label, 6-week study.
6/2008	Five-year efficacy and safety of levodopa/DDCI and entacapone in patients with Parkinson's disease.
5/2005	Entacapone increases levodopa exposure and reduces plasma levodopa variability when used with Sinemet CR.

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Mika Leinonen Research Topics

Disease

13	Parkinson Disease (Parkinson's Disease) 01/2021 - 05/2005
6	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 01/2016
5	Neoplasms (Cancer) 01/2016 - 02/2006
5	Breast Neoplasms (Breast Cancer) 02/2014 - 02/2006
3	Dyskinesias (Dyskinesia) 01/2020 - 07/2012
3	Heart Failure 02/2014 - 02/2006
3	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 03/2013 - 09/2011
2	Mitochondrial Diseases (Mitochondrial Disease) 10/2020 - 09/2011
2	Disease Progression 01/2016 - 06/2012
2	Neoplasm Metastasis (Metastasis) 08/2014 - 12/2009
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 08/2014 - 03/2012
2	Blindness (Hysterical Blindness) 05/2012 - 09/2011
1	Sleepiness 01/2020
1	Heart Arrest (Cardiac Arrest) 01/2020
1	Dizziness (Lightheadedness) 01/2020
1	Nausea 01/2020
1	Lung Diseases (Lung Disease) 11/2018
1	Stomatitis 01/2016
1	Hematologic Neoplasms (Hematological Malignancy) 01/2016
1	Cryopyrin-Associated Periodic Syndromes 01/2016
1	Injection Site Reaction 01/2016
1	Sarcoma (Soft Tissue Sarcoma) 08/2014
1	Rupture 08/2014
1	Left Ventricular Dysfunction 02/2014
1	Body Weight (Weight, Body) 07/2013
1	Parkinsonian Disorders (Parkinsonism) 07/2012
1	Metabolic Diseases (Metabolic Disease) 09/2011
1	Hand-Foot Syndrome 12/2009
1	Febrile Neutropenia 12/2009
1	Neutropenia 12/2009
1	Alzheimer Disease (Alzheimer's Disease) 10/2009

Drug/Important Bio-Agent (IBA)

12	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 05/2005
7	idebenoneIBA 10/2020 - 09/2011
5	entacapone (Comtan)FDA Link 12/2015 - 05/2005
5	Epirubicin (Ellence)FDA LinkGeneric 02/2014 - 02/2006
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/2014 - 02/2006
5	Fluorouracil (Carac)FDA LinkGeneric 02/2014 - 02/2006
5	Docetaxel (Taxotere)FDA Link 02/2014 - 02/2006
4	Carbidopa (Lodosyn)FDA LinkGeneric 01/2021 - 03/2010
3	Trastuzumab (Herceptin)FDA Link 02/2014 - 02/2006
3	Capecitabine (Xeloda)FDA Link 02/2014 - 12/2009
2	BenserazideIBA 12/2015 - 03/2010
2	Imatinib Mesylate (Gleevec)FDA Link 08/2014 - 03/2012
2	Mitochondrial DNA (mtDNA)IBA 05/2012 - 09/2011
2	AnthracyclinesIBA 01/2012 - 12/2009
2	taxaneIBA 01/2012 - 12/2009
2	Vinorelbine (Navelbine)FDA LinkGeneric 12/2009 - 02/2006
1	VBP15 compoundIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 10/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 10/2020
1	Lipopolysaccharide ReceptorsIBA 10/2020
1	AlbuminsIBA 10/2020
1	Growth Differentiation Factor 15IBA 10/2020
1	Retinaldehyde (Retinal)IBA 10/2020
1	EnzymesIBA 01/2020
1	Amino Acids FDA Link 01/2020
1	Carboxy-LyasesIBA 01/2020
1	Aromatic-L-Amino-Acid DecarboxylasesIBA 01/2020
1	Apomorphine FDA Link 01/2020
1	Dopamine (Intropin)FDA LinkGeneric 01/2020
1	GlucocorticoidsIBA 11/2018
1	Pramipexole (Mirapex)FDA LinkGeneric 01/2017
1	rasagiline (Azilect)FDA Link 01/2017
1	PowdersIBA 10/2016
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2016
1	Fibroblast Growth Factor 7 FDA Link 01/2016
1	StalevoIBA 07/2013
1	fipamezoleIBA 07/2012
1	VaccinesIBA 06/2012
1	human ERBB2 proteinIBA 12/2009
1	Amyloid beta-PeptidesIBA 10/2009
1	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 10/2009
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 05/2005
1	Aromatic Amino Acid Decarboxylase InhibitorsIBA 05/2005

Therapy/Procedure

3	Therapeutics 10/2020 - 07/2013
3	Drug Therapy (Chemotherapy) 02/2014 - 12/2009
1	Oral Administration 01/2019
1	Activities of Daily Living (ADL) 01/2017
1	Nebulizers and Vaporizers (Inhaler) 10/2016
1	Hematopoietic Stem Cell Transplantation 01/2016
1	Adjuvant Chemotherapy 12/2009